gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells and its Fc engages FcγR+ effector cells (e.g., NK cells) to mediate antibody‑dependent cellular cytotoxicity; it can also activate complement and block HER2 signaling, promoting apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain IV; blocks HER2 signaling/dimerization; mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427252
disease_id_num_tar_ref
145
drug_id_num_tar_ref
395