gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD20 on B cells and triggers FcγRIIIa-mediated ADCC by NK cells and phagocytosis by macrophages; also induces direct, caspase‑independent cell death (with reduced reliance on complement).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
type II anti-CD20 binding; glycoengineered Fc enhances ADCC via FcγRIIIa
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06552572
disease_id_num_tar_ref
1317
drug_id_num_tar_ref
3570