gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs recognize the tumor-derived peptide presented by HLA-C via their native TCRs and directly kill target cells through perforin/granzyme-mediated cytolysis (and death receptor pathways).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Patient-specific peptide–MHC complex; polyclonal TCR repertoire
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06532799
disease_id_num_tar_ref
1330
drug_id_num_tar_ref
3603