gene_symbol
HLA-DRB1
hgnc_id
HGNC:4948
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD4+ TILs recognize tumor-derived peptide–HLA-DR via their native TCRs and directly kill the presenting cell through perforin/granzyme release and Fas–FasL apoptosis, with IFN-γ/TNF-α aiding cytotoxicity.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Patient-specific peptide–MHC complex; CD4+ TCR restriction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06532799
disease_id_num_tar_ref
1330
drug_id_num_tar_ref
3603