gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Imvotamab engages CD3 on T cells to activate them; these T cells kill CD20+ B cells via perforin/granzyme and complement-dependent cytotoxicity. CD3+ T cells are not the cells being killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 complex (epsilon chain)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06087406
disease_id_num_tar_ref
1333
drug_id_num_tar_ref
3612