gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-mediated ADCC: trastuzumab binds HER2 and engages Fcγ receptors on NK cells/other effectors to kill target cells; signaling blockade can also induce apoptosis/growth arrest.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (subdomain IV) to inhibit signaling and mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07062263
disease_id_num_tar_ref
1337
drug_id_num_tar_ref
3616