gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
PD-L1 engagement provides an activating costimulatory signal via the PD-1 switch receptor but does not target cells for lysis; cytotoxicity occurs only when the CAR binds CD56, triggering perforin/granzyme-mediated killing of CD56+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged via PD-1 extracellular-domain switch receptor to convert inhibitory PD-1/PD-L1 signals into activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05941156
disease_id_num_tar_ref
1346
drug_id_num_tar_ref
3637