gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Ipilimumab binds CTLA-4 on T cells (especially intratumoral Tregs); its IgG1 Fc engages Fc-gamma receptors on NK cells/macrophages to mediate ADCC/ADCP, depleting CTLA-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc can engage Fc-gamma receptors (e.g., FCGR3A/CD16A) to mediate ADCC/ADCP of CTLA-4+ Tregs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06784648
disease_id_num_tar_ref
1347
drug_id_num_tar_ref
3641