gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR on infused T cells binds CD19 on target cells, triggering CD3ζ/co‑stimulatory signaling that activates the T cells to kill CD19+ cells via perforin/granzyme and death‑receptor–mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen; CAR scFv binds extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06464185
disease_id_num_tar_ref
1353
drug_id_num_tar_ref
3658