gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody-drug conjugate binds CD22, is internalized, and releases calicheamicin, which induces DNA double-strand breaks leading to apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-lineage cell surface glycoprotein (also known as SIGLEC2)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06025682
disease_id_num_tar_ref
1355
drug_id_num_tar_ref
3664