gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
STI-6129 targets CD38 on the cell surface, is internalized, and releases an MMAF payload that binds the vinca site on β-tubulin to block polymerization, causing G2/M arrest and apoptosis. Tubulin expression alone does not lead to killing; only CD38+ cells are targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target; MMAF/DUO-5.2 inhibits tubulin polymerization via the vinca site
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05692908
disease_id_num_tar_ref
1364
drug_id_num_tar_ref
3701