gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blinatumomab binds CD3 on T cells to activate them; the activated T cells kill CD19-positive cells via perforin/granzyme after immune-synapse formation. CD3+ T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor CD3 complex epsilon chain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05837689
disease_id_num_tar_ref
1369
drug_id_num_tar_ref
3708