gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP2 on target cells, is internalized, and releases a topoisomerase I inhibitor payload that induces DNA damage/replication arrest, leading to apoptosis (with possible bystander killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface tumor-associated antigen targeted by ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06711900
disease_id_num_tar_ref
1374
drug_id_num_tar_ref
3721