gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Reinfused TILs use native TCRs to recognize the tumor-derived peptide–HLA class II complex and directly kill the presenting cell via perforin/granzyme-mediated cytolysis, supported by cytokines (e.g., IFN-γ, TNF-α).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized by CD4+ TILs; HLA-DR/DP/DQ restricted; peptides include neoantigens and shared TAAs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05868915
disease_id_num_tar_ref
1375
drug_id_num_tar_ref
3726