gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Isatuximab binds CD38 on target cells and induces Fc-mediated ADCC and ADCP, activates complement (CDC), and can trigger direct apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibits CD38 ectoenzyme (NADase/ADPR cyclase) activity; IgG1 Fc mediates ADCC/CDC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05690984
disease_id_num_tar_ref
1377
drug_id_num_tar_ref
3732