gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CARv3 T cells bind EGFRvIII on tumor cells, form an immunologic synapse, and kill via T‑cell cytotoxic mechanisms (perforin/granzyme and apoptosis pathways).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CARv3 scFv recognizes the EGFRvIII-specific neoepitope (exons 2–7 deletion mutant)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05660369
disease_id_num_tar_ref
1387
drug_id_num_tar_ref
3754