gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The engineered T cells secrete an EGFR×CD3 bispecific (TEAM-E) that binds EGFR on tumor cells and CD3 on T cells, recruiting and activating T cells to kill EGFR+ cells via perforin/granzyme (and Fas/FasL) cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
EGFR-binding arm of the secreted TEAM-E (EGFR×CD3) bispecific
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05660369
disease_id_num_tar_ref
1387
drug_id_num_tar_ref
3754