gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3 on T cells is engaged by the secreted EGFR×CD3 T‑cell engager to activate and recruit T cells; CD3+ cells are not targeted for killing—cytotoxicity is directed at EGFRvIII/EGFR-expressing tumor cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3-binding arm of the secreted TEAM-E engages endogenous T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05660369
disease_id_num_tar_ref
1387
drug_id_num_tar_ref
3754