gene_symbol
CDH17
hgnc_id
HGNC:1756
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CDH17 on target cells and induce T‑cell–mediated cytotoxicity via perforin/granzyme release (and Fas–FasL apoptosis), leading to direct lysis of CDH17-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface cadherin on gastrointestinal epithelial/tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06055439
disease_id_num_tar_ref
1394
drug_id_num_tar_ref
3772