gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Disitamab vedotin targets HER2, is internalized, and releases MMAE; MMAE then binds the beta‑tubulin vinca domain to inhibit microtubules, causing G2/M arrest and apoptosis. Killing depends on HER2-mediated delivery (or bystander uptake), not on beta‑tubulin expression itself.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds β-tubulin at the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05943379
disease_id_num_tar_ref
1395
drug_id_num_tar_ref
3775