gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its IgG1 Fc engages FcγR-expressing immune cells (e.g., NK cells) to mediate antibody‑dependent cellular cytotoxicity (and some complement activation), leading to lysis of EGFR-positive cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain (ligand-binding site); blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06379399
disease_id_num_tar_ref
157
drug_id_num_tar_ref
426