gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the KRAS G12V peptide presented by HLA-C*08:02 and directly kill target cells via TCR-triggered cytotoxicity, primarily through perforin/granzyme-mediated apoptosis.
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
pMHC class I complex; allele restriction: HLA-C*08:02
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06487377
disease_id_num_tar_ref
1396
drug_id_num_tar_ref
3777