gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds EGFR on target cells and its IgG1 Fc engages Fcγ receptor–bearing immune cells, leading to antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP). Receptor internalization/degradation inhibits signaling but killing is primarily immune-mediated.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds wild-type and certain mutant forms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06083857
disease_id_num_tar_ref
1398
drug_id_num_tar_ref
3782