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gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific antibody binds CD20 on B cells and presents SIRPα to block CD47, removing the “don’t‑eat‑me” signal and promoting macrophage phagocytosis (ADCP). Its IgG1 Fc engages Fcγ receptors to recruit NK cells/macrophages for ADCC, leading to direct immune effector killing of CD20+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; anchoring target for localized CD47 blockade
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05771883
disease_id_num_tar_ref
1406
drug_id_num_tar_ref
3801