gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IMM0306 anchors to CD20 on B cells and locally blocks CD47–SIRPalpha, removing the don't-eat-me signal to enable macrophage phagocytosis and Fc receptor–mediated ADCC of CD20+ cells; CD47 expression alone is not sufficient for targeting.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Binding via SIRPα domain; CD47 blockade gated/enhanced by co-engagement of CD20 on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05771883
disease_id_num_tar_ref
1406
drug_id_num_tar_ref
3801