gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells, inducing type II direct (caspase‑independent) cell death and engaging FcγRIIIa on effector cells to drive ADCC/ADCP (with reduced CDC), leading to B‑cell killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 epitope; glycoengineered Fc enhances ADCC with reduced CDC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05995054
disease_id_num_tar_ref
1407
drug_id_num_tar_ref
3803