gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages FcγRIIIa (CD16a) on NK cells/macrophages to trigger ADCC/ADCP against CD20+ cells. CD16a+ cells act as effectors and are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Afucosylated Fc increases affinity to FcγRIIIa; mediates ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05995054
disease_id_num_tar_ref
1407
drug_id_num_tar_ref
3803