gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2, is internalized, and releases MMAE, which binds beta‑tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis; tubulin expression alone does not make cells targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload (MMAE) binds the Vinca domain to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06003231
disease_id_num_tar_ref
1410
drug_id_num_tar_ref
3810