gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-targeted ADC binds HER2, is internalized, and releases a camptothecin/topoisomerase I–inhibiting payload that causes DNA damage, blocks replication, and induces apoptosis in the HER2-expressing cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; includes HER2-low expression
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06340230
disease_id_num_tar_ref
1414
drug_id_num_tar_ref
3822