gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds EGFR on target cells and engages immune effectors via its IgG1 Fc to induce ADCC and complement-mediated lysis (CDC); receptor blockade/internalization may contribute to cell death.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds wild-type and select mutant forms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06385080
disease_id_num_tar_ref
1420
drug_id_num_tar_ref
3836