gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds MET on target cells and engages Fc receptors to trigger ADCC and complement-dependent cytotoxicity (CDC), with additional receptor downregulation/signaling blockade.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds wild-type and select mutant forms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06385080
disease_id_num_tar_ref
1420
drug_id_num_tar_ref
3836