gene_symbol
PRAME
hgnc_id
HGNC:9336
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Affinity‑enhanced TCR binds PRAME peptide–HLA‑A*02:01 on tumor cells while anti‑CD3 engages T cells, forming an immune synapse and triggering T‑cell–mediated killing (perforin/granzymes, apoptosis) of PRAME/HLA‑A*02:01–positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide-HLA (pHLA) complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06112314
disease_id_num_tar_ref
166
drug_id_num_tar_ref
450