gene_symbol
CD52
hgnc_id
HGNC:1804
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Alemtuzumab binds CD52 on target cells and recruits immune effectors, causing complement-dependent cytotoxicity and Fc-mediated ADCC/ADCP, leading to depletion of CD52+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface glycoprotein expressed on mature lymphocytes and other immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05501756
disease_id_num_tar_ref
1424
drug_id_num_tar_ref
3848