gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine primes tumor-specific T cells. Vaccine-activated CD4+ T cells recognizing GBM neoantigen peptides on HLA class II can exert cytotoxicity, and they also help activate CD8+ CTLs that kill tumor cells via perforin/granzyme and Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ T-cell targets (MHC II)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05100641
disease_id_num_tar_ref
8
drug_id_num_tar_ref
16