gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug engages CD3ε on T cells to activate and recruit them to PRAME/HLA-A*02:01–positive tumor cells; the T cells then kill the PRAME+ tumor cells (perforin/granzyme), not the CD3+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
part of the T-cell receptor/CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06112314
disease_id_num_tar_ref
166
drug_id_num_tar_ref
450