gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CLDN18.2, is internalized, linker cleaved in lysosomes, releasing a cytotoxic payload that induces DNA damage and kills the target-expressing cell (with possible bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Stomach-specific A2 isoform expressed on epithelial cancers
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05867563
disease_id_num_tar_ref
1431
drug_id_num_tar_ref
3868