gene_symbol
EPCAM
hgnc_id
HGNC:11529
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
A bispecific T‑cell engager binds EpCAM on tumor cells and CD3 on T cells (activated in the acidic TME), forming immune synapses that activate cytotoxic T cells to kill EpCAM+ cells via perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
pH-dependent CAB activation in acidic tumor microenvironment
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05808634
disease_id_num_tar_ref
1433
drug_id_num_tar_ref
3876