gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
BA3182 binds CD3ε on T cells and EpCAM on tumor cells; in the tumor microenvironment it activates and redirects T cells to kill EpCAM-positive cancer cells via immune-synapse formation and perforin/granzyme-mediated cytotoxicity. CD3ε-expressing T cells are not the cells killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
T-cell engagement arm; pH-dependent CAB activation in acidic tumor microenvironment
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05808634
disease_id_num_tar_ref
1433
drug_id_num_tar_ref
3876