gene_symbol
CCR8
hgnc_id
HGNC:1609
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 anti-CCR8 antibody binds CCR8 on target cells and recruits FcγR-expressing effector cells (e.g., NK cells) to mediate ADCC, depleting CCR8+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPCR on intratumoral Tregs; blocks CCR8 signaling and enables ADCC-mediated depletion of CCR8+ Tregs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05859464
disease_id_num_tar_ref
1440
drug_id_num_tar_ref
3897