gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-HER2 ADC binds HER2, is internalized, and releases a topoisomerase I (camptothecin-class) cytotoxic payload that causes DNA damage and apoptosis; Fc effector function may add ADCC.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06423885
disease_id_num_tar_ref
1445
drug_id_num_tar_ref
3910