gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 on target cells, activate, form an immunologic synapse, and kill via perforin/granzyme-mediated cytolysis (and Fas/FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; CAR binds extracellular domain epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06093841
disease_id_num_tar_ref
1450
drug_id_num_tar_ref
3921