gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An expressed bispecific T‑cell engager binds GPC3 on tumor cells and CD3 on T cells, forming a cytolytic synapse that activates T cells to kill GPC3+ cells via perforin/granzyme-mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen on hepatocellular carcinoma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06689540
disease_id_num_tar_ref
1455
drug_id_num_tar_ref
3937