gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA produces a bispecific T‑cell engager that binds CD3ε on T cells and GPC3 on tumor cells, activating T cells to kill GPC3+ cancer cells (perforin/granzyme). CD3ε-expressing T cells are engaged, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor complex component targeted for T-cell engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06689540
disease_id_num_tar_ref
1455
drug_id_num_tar_ref
3937