gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
GPC3-specific CAR-T cells bind GPC3 on target cells, triggering CAR signaling and T-cell cytotoxicity with perforin/granzyme release (apoptotic lysis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface oncofetal heparan sulfate proteoglycan overexpressed on hepatocellular carcinoma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06461624
disease_id_num_tar_ref
1462
drug_id_num_tar_ref
3950