gene_symbol
CCR8
hgnc_id
HGNC:1609
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds CCR8 on Tregs and engages Fcγ receptors on NK cells/macrophages to mediate ADCC, depleting CCR8+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CCL1–CCR8 signaling; Fc-mediated ADCC to deplete CCR8+ Tregs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06620822
disease_id_num_tar_ref
172
drug_id_num_tar_ref
463