gene_symbol
CD28
hgnc_id
HGNC:1653
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD28+ T cells receive costimulatory activation from the bispecific (via CD28 engagement) while it binds EGFR on tumor cells; activated T cells then kill EGFR-expressing tumor cells. CD28-expressing cells themselves are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
CD28 costimulation is conditionally delivered upon simultaneous engagement of EGFR on target cells (bispecific gating).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06465329
disease_id_num_tar_ref
1467
drug_id_num_tar_ref
3967