gene_symbol
CLDN6
hgnc_id
HGNC:2048
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific antibody engages CD3 on T cells and CLDN6 on tumor cells, forming an immune synapse that activates T cells to kill CLDN6+ cells via perforin/granzyme–mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated tight junction protein on CLDN6-positive solid tumors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06681870
disease_id_num_tar_ref
1484
drug_id_num_tar_ref
4018