gene_symbol
SLAMF7
hgnc_id
HGNC:21394
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific antibody–armed autologous T cells are bridged to SLAMF7 on target cells via elotuzumab and to CD3 on T cells via OKT3, forming an immune synapse and inducing T‑cell cytotoxicity (perforin/granzyme-mediated lysis) of SLAMF7+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as CS1/CRACC/CD319; bound by elotuzumab
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04864522
disease_id_num_tar_ref
1488
drug_id_num_tar_ref
4023