gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Anti-CD3 (OKT3) binds CD3ε on T cells to activate and link them to SLAMF7+ myeloma via elotuzumab; CD3+ T cells act as effectors and kill SLAMF7-expressing tumor cells via immune synapse and perforin/granzyme release, not the CD3+ cells themselves.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of OKT3 (muromonab-CD3) on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04864522
disease_id_num_tar_ref
1488
drug_id_num_tar_ref
4023