gene_symbol
SLAMF7
hgnc_id
HGNC:21394
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Elotuzumab binds SLAMF7 on myeloma cells and its Fc engages Fcγ receptors on NK cells to trigger ADCC, while also co-activating NK cells via SLAMF7 signaling, leading to lysis of SLAMF7+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary tumor antigen on multiple myeloma; also expressed on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04864522
disease_id_num_tar_ref
1488
drug_id_num_tar_ref
4024